Two sample MR report
KANSL1-AS1_Dendritic Cell (DC) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 45 | 0.1069073 | 0.1488621 | 0.4765408 |
| Weighted median | 45 | -0.0906007 | 0.0130159 | 0.0000000 |
| Inverse variance weighted | 45 | -0.0733073 | 0.0100553 | 0.0000000 |
| Simple mode | 45 | -0.0943393 | 0.0244930 | 0.0003769 |
| Weighted mode | 45 | -0.0938611 | 0.0247405 | 0.0004493 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 25.03678 | 43 | 0.9869898 |
| Inverse variance weighted | 26.50909 | 44 | 0.9829108 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1533948 | 0.1264189 | 0.2316058 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004658 | 0 | TRUE | 0.0408383 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
